Developing an SCN8A ASO with PhD Student, Sophie Hill

The Central Dogma

Image: Genome Research Limited

NaV 1.6 SCN8A Sodium Channel

Image: https://www.neuroscientificallychallenged.com/glossary/ion-channel

What is an ASO?

SCN8A ASO: Lenk et al., 2020, Ann. Neurol.

How were the ASOs Tested?

SCN8A ASO Reduces SCN8A Transcript Levels: Lenk et al., 2020, Ann. Neurol.
Mouse with SCN8A Gain of Function Mutation: Bunton-Stasyshyn and Wagnon et al., 2019, Brain
ASO Extends Survival in SCN8A Mutant Mice: Lenk et al., 2020, Ann. Neurol.

Potential Side Effects

Next Steps

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